Background and Objective: Today, the role of religiosity, happiness, locus of control and coping strategies has been considered in prevention and treatment of general health and spiritual well-being problems. Concerning the importance of nursing, this research aimed to investigate the relationship between religious orientation, happiness, locus of control and coping strategies and spiritual well-being among nursing students.

Material and Methods: This correlational study was conducted on 140 selected via stratified random sampling among 228 nursing students of Islamic Azad University of Pishva in 2013-14 academic year. The questionnaires were Allport & Ross religiosity (1967), Argyle & Lu happiness (1990), Rotter locus of control (1975), Lazarus & Folkaman coping strategies (1993) and Paloutzin & Ellison spiritual well-being (1982). The data was analyzed by stepwise regression using SPSS-19 software.

Results: The findings showed that the internal religiosity orientation (r=0.48), happiness (r=0.34), internal locus of control (r=0.19) and problem solving strategies (r=0.17) had a positive significant correlation with spiritual well-being and external locus of control (r=-0.21) had a negative significant relationship with spiritual well-being.  The Internal religiosity orientation, external locus of control and happiness could predict 37 percent of variance of spiritual well-being in that the share of internal religiosity orientation variable was 23 percent.

Conclusion: Given the importance of internal religiosity orientations, external locus of control and happiness in predicting spiritual well-being, we recommend that programmers, therapists and psychosocial counselors consider them in their programs to promote spiritual well-being of nursing students.