Volume 20, Issue 1 (4-2023)
J Res Dev Nurs Midw 2023, 20(1): 66-72 |
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chegini M, hajizade K, farshbaf A, lalooha F, Shahnazi M. Comparative efficacy of combined oral contraceptive capsules and vitamin D–combined oral contraceptive capsules on ovulatory dysfunction: A randomized clinical trial. J Res Dev Nurs Midw 2023; 20 (1) :66-72
URL: http://nmj.goums.ac.ir/article-1-1478-en.html
URL: http://nmj.goums.ac.ir/article-1-1478-en.html
1- Department of Midwifery, Faculty of Nursing and Midwifery, Qazvin University of Medical sciences, Qazvin, Iran
2- Department of Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
3- Physical Medicine and Rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
4- Obstetrics and Gynecology Department, School of Medicine, Kosar Teaching Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
5- Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran , shahnazimahnaz@gmail.com
2- Department of Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran
3- Physical Medicine and Rehabilitation Research Centre, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
4- Obstetrics and Gynecology Department, School of Medicine, Kosar Teaching Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
5- Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran , shahnazimahnaz@gmail.com
Abstract: (162 Views)
Background: Food intake and metabolism might play central roles in causing and treating menstrual disorders. Vitamin D may lead to the improvement of folliculogenesis through anti-Mullerian hormone (AMH). This study aimed to compare the effect of vitamin D intake with that of the combined oral contraceptive (COC) capsules on ovulatory dysfunction.
Methods: This study was conducted on 60 eligible women referred to Kowsar Qazvin Hospital with a complaint of abnormal uterine bleeding (AUB). They had a history of excessive, long, and irregular bleeding. The participants in the control and intervention groups received 1 oral LD capsule and a combination of vitamin D and LD capsules on a daily basis for 3 months, respectively. The menstrual bleeding volume, the number of menstrual days, and the menstrual cycle length were evaluated before, during, and after the intervention. The Mann-Whitney U test, Friedman test, independent t test, and Cochran Q test were used in SPSS version 24 for data analysis. P values less than 0.05 were considered statistically significant.
Results: The menstrual bleeding intensity decreased significantly in the intervention group (vitamin D–LD capsule; P = 0.001). Over time, both intervention and control groups showed a significant improvement in the number of menstrual days and menstrual cycle length, resulting in a more normal menstrual cycle. However, these 2 parameters remained more natural in the intervention group, a finding which did not indicate any significant differences.
Conclusion: Vitamin D can be used along with LD capsules as a supplementary treatment to lessen menstrual bleeding intensity.
Methods: This study was conducted on 60 eligible women referred to Kowsar Qazvin Hospital with a complaint of abnormal uterine bleeding (AUB). They had a history of excessive, long, and irregular bleeding. The participants in the control and intervention groups received 1 oral LD capsule and a combination of vitamin D and LD capsules on a daily basis for 3 months, respectively. The menstrual bleeding volume, the number of menstrual days, and the menstrual cycle length were evaluated before, during, and after the intervention. The Mann-Whitney U test, Friedman test, independent t test, and Cochran Q test were used in SPSS version 24 for data analysis. P values less than 0.05 were considered statistically significant.
Results: The menstrual bleeding intensity decreased significantly in the intervention group (vitamin D–LD capsule; P = 0.001). Over time, both intervention and control groups showed a significant improvement in the number of menstrual days and menstrual cycle length, resulting in a more normal menstrual cycle. However, these 2 parameters remained more natural in the intervention group, a finding which did not indicate any significant differences.
Conclusion: Vitamin D can be used along with LD capsules as a supplementary treatment to lessen menstrual bleeding intensity.
Keywords: combined oral contraceptive, abnormal uterine bleeding (AUB), menstrual bleeding, vitamin D
Type of Study: Original Article |
Subject:
Midwifery
References
1. Motta T, Laganà AS, Vitale SG. Dysfunctional Uterine Bleeding. Good Practice in Pediatric and Adolescent Gynecology: Springer; 2018. p.99-115. [View at Publisher] [DOI] [Google Scholar]
2. Vladimirovna SV, Anvarovna SL, Vladimirovna ME, Khidirovna LZJCAJoM, Science N. Menstrual Cycle Disturbances in the Reproductive Period. Central Asian Journal of Medical and Natural Science.2023;4(2):389-97. [View at Publisher] [Google Scholar]
3. Kazemijaliseh H, Tehrani FR, Behboudi-Gandevani S, Khalili D, Hosseinpanah F, Azizi FJAoIM. A Population-Based Study of the Prevalence of Abnormal Uterine Bleeding and its Related Factors among Iranian Reproductive-Age Women: An Updated Data. Archives of Iranian Medicine. 2017;20(9). [View at Publisher] [PMID] [Google Scholar]
4. Samani RO, Hashiani AA, Razavi M, Vesali S, Rezaeinejad M, Maroufizadeh S, et al. The prevalence of menstrual disorders in Iran: A systematic review and meta-analysisInternational Journal of Reproductive BioMedicine. 2018;16(11): 665-78. [View at Publisher] [DOI] [PMID] [Google Scholar]
5. Yaşa C, Uğurlucan FGJJocripe. Approach to abnormal uterine bleeding in adolescents. Journal of Clinical Research in Pediatric Endocrinology, 2020;12(Suppl 1):1-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
6. Sriprasert I, Pakrashi T, Kimble T, Archer DFJC, medicine r. Heavy menstrual bleeding diagnosis and medical management. Contraception and Reproductive Medicine. 2017;2(1):1-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
7. Liu Z, Doan QV, Blumenthal P, Dubois RWJVih. A systematic review evaluating health‐related quality of life, work impairment, and health‐care costs and utilization in abnormal uterine bleeding. Value Health. 2007;10(3):183-94. [View at Publisher] [DOI] [PMID] [Google Scholar]
8. Kaunitz AM, Levine D. Abnormal uterine bleeding in nonpregnant reproductive-age patients: Terminology, evaluation, and approach to diagnosis. 2021. UpToDate. 2023.
9. Jensen JT, Lefebvre P, Laliberté F, Sarda SP, Law A, Pocoski J, et al. Cost burden and treatment patterns associated with management of heavy menstrual bleeding Journal of Women's Health. 2012;21(5):539-47. [View at Publisher] [DOI] [PMID] [Google Scholar]
10. Apgar BS, Kaufman AH, George-Nwogu U, Kittendorf ALJAFP. Treatment of menorrhagia. Am Fam Physician. 2007;75(12):1813-9. [View at Publisher] [PMID] [Google Scholar]
11. Berek JS, Novak E. Berek and Novak's gynecology. 16th ed. Philadelphia: Lippincott Williams & Wilkins; 2020. 396-405. [View at Publisher]
12. Kaunitz AM, Levine DJU. Abnormal uterine bleeding in nonpregnant reproductive-age patients: Terminology, evaluation, and approach to diagnosis. UpToDate. 2023. [View at Publisher] [Google Scholar]
13. Geetha B, Shameem I. Efficacy of Unani formulations in the management of dysfunctional uterine bleeding-A randomized controlled trial. International Journal of Medical and Health Research. 2016;2(5):57-61. [View at Publisher] [Google Scholar]
14. Durain DJJom, health ws. Primary dysmenorrhea: assessment and management update. Journal of midwifery & women's health. 2004;49(6):520-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
15. Proctor M, Murphy PJTCL. Herbal and dietary therapies for primary and secondary dysmenorrhoea. Cochrane Libr. 2005(2).
16. Rafeeq H, Ahmad S, Tareen MB, Shahzad KA, Bashir A, Jabeen R, Shehzadi I. Biochemistry of fat soluble vitamins, sources, biochemical functions and toxicity. Haya: The Saudi Journal of Life Sciences. 2020;5(6):188-96. [View at Publisher] [DOI] [Google Scholar]
17. Pludowski P, Holick MF, Grant WB, Konstantynowicz J, Mascarenhas MR, Haq A, et al. Vitamin D supplementation guidelines. The Journal of Steroid Biochemistry and Molecular Biology. 2018;175:125-35. [View at Publisher] [DOI] [PMID] [Google Scholar]
18. Esmaeili SA, Mohammadian S, Radbakhsh S, Momtazi-Borojeni AA, Parizi KP. AtabatiHadi, MardaniF, Saburi E, Moghaddam AS. Evaluation of vitamin D3 deficiency: a population-based study in northeastern Iran. Journal of Cellular Biochemistry. 2019;120(6):10337-41. [View at Publisher] [DOI] [PMID] [Google Scholar]
19. Baird DD, Hill MC, Schectman JM, Hollis BWJE. Vitamin D and risk of uterine fibroids. Epidemiology. 2013;24(3):447. [View at Publisher] [DOI] [PMID] [Google Scholar]
20. Rashidi B, Haghollahi F, Shariat M, Zayerii FJTJoO, Gynecology. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol. 2009;48(2):142-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
21. Dicken CL, Israel DD, Davis JB, Sun Y, Shu J, Hardin J, et al. Peripubertal vitamin D3 deficiency delays puberty and disrupts the estrous cycle in adult female mice. Biology of Reproduction. 2012;87(2):51,1-12. [View at Publisher] [DOI] [PMID] [Google Scholar]
22. Luk J, Torrealday S, Neal Perry G, Pal LJHr. Relevance of vitamin D in reproduction. Human reproduction. 2012;27(10):3015-27. [View at Publisher] [DOI] [PMID] [Google Scholar]
23. Zec I, Tislaric-Medenjak D, Bukovec Megla Z, Kucak IJBm. Anti-Mullerian hormone: a unique biochemical marker of gonadal development and fertility in humans. Biochem Medica. 2011;21(3):219-30. [View at Publisher] [DOI] [PMID] [Google Scholar]
24. Irani M, Merhi ZJF, sterility. Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertility and Sterility. 2014;102(2):460-8. [View at Publisher] [DOI] [PMID] [Google Scholar]
25. Cashman KDJCti. Vitamin D deficiency: defining, prevalence, causes, and strategies of addressing. Calcified tissue international. 2020;106(1):14-29. [View at Publisher] [DOI] [PMID] [Google Scholar]
26. Grzechocińska B, Warzecha D, Szymusik I, Sierdziński J, Wielgoś MJNL. 25 (OH) D serum concentration in women with menstrual disorders-risk factors for vitamin D deficiency. Neuroendocrinology Letters. 2018;39(3).219-25. [View at Publisher] [PMID] [Google Scholar]
27. Tabrizi R, Moosazadeh M, Akbari M, Dabbaghmanesh MH, Mohamadkhani M, Asemi Z, et al. High prevalence of vitamin D deficiency among Iranian population: a systematic review and meta-analysis. Iranian Journal of Medical Sciences. 2018;43(2):125-39. [View at Publisher] [DOI] [PMID] [Google Scholar]
28. Lips PJTJosb. Vitamin D status and nutrition in Europe and Asia. Lips PJTJosb, biology m. Vitamin D status and nutrition in Europe and Asia. The Journal of Steroid Biochemistry and Molecular Biology. 2007;103(3-5):620-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
29. Jukic AMZ, Steiner AZ, Baird DDJRB, Endocrinology. Lower plasma 25-hydroxyvitamin D is associated with irregular menstrual cycles in a cross-sectional study. Reproductive Biology and Endocrinology. 2015;13(1):1-6. [View at Publisher] [DOI] [PMID] [Google Scholar]
30. Łagowska KJN. The relationship between vitamin D status and the menstrual cycle in young women: a preliminary study. Nutrients. 2018;10(11):1729. [View at Publisher] [DOI] [PMID] [Google Scholar]
31. Jukic AMZ, Upson K, Harmon QE, Baird DDJF, sterility. Increasing serum 25-hydroxyvitamin D is associated with reduced odds of long menstrual cycles in a cross-sectional study of African American women. Fertil Steril. 2016;106(1):172-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
32. Bashmakova N, Lisovskaya T, Vlasova VJGE. Pathogenetic role of vitamin D deficiency in the development of menstrual dysfunction in pubertal girls: a literature review. Gynecol Endocrinol. 2017;33(sup1):52-5. [View at Publisher] [DOI] [PMID] [Google Scholar]
33. Higham JM, O'brien PM, Shaw R. Assessment of menstrual blood loss using a pictorial chart. BJOG: An International Journal of Obstetrics & Gynaecology. 1990 Aug;97(8):734-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
34. Taylor CL, Patterson KY, Roseland JM, Wise SA, Merkel JM, Pehrsson PR, et al. Including food 25-hydroxyvitamin D in intake estimates may reduce the discrepancy between dietary and serum measures of vitamin D status. The Journal of Nutrition. 2014;144(5):654-9. [View at Publisher] [DOI] [PMID] [Google Scholar]
35. Zakherah MS, Sayed GH, El-Nashar SA, Shaaban MMJG, investigation o. Pictorial blood loss assessment chart in the evaluation of heavy menstrual bleeding: diagnostic accuracy compared to alkaline hematin. Gynecologic and Obstetric Investigation. 2011;71(4):281-4. [View at Publisher] [DOI] [PMID] [Google Scholar]
36. Mehrabian F, Abbassi FJPJoMS. Comparing the effects of low-dose contraceptive pills to control dysfunctional uterine bleeding by oral and vaginal methods. Pakistan Journal of Medical Sciences. 2013;29(5):1208. [View at Publisher] [DOI] [PMID] [Google Scholar]
37. Adawiyah R, Mulyantoro I, Dewantiningrum J, Pramono NJJoB, Research T. Randomized Controlled Trial of Tranexamic Acid's Effect on Bleeding Length: A Study on DMPA Users with Abnormal Uterine Bleeding Who Receive Low-Dose Oral Contraceptive Pill . Journal of Biomedicine and Translational Research. 2020;6(1):1-5. [View at Publisher] [DOI] [Google Scholar]
38. Jain S, Vaid NB, Narang Y, Suneja A, Guleria KJJoc, JCDR dr. A randomised controlled trial comparing the efficacy and side-effects of intravaginal ring (Nuvaring®) with combined oral hormonal preparation in dysfunctional uterine bleeding. Journal of Clinical and Diagnostic Research. 2016;10(3):QC21. [View at Publisher] [DOI] [PMID] [Google Scholar]
39. Rahmanian M, Saghafi M, Darban M, Mirmohammadkhani MJMEJoR, Health. Is Vitamin D Effective in the Treatment of Uterine Leiomyoma? A Randomized Controlled Double-Blind Clinical Trial. Middle East Journal of Rehabilitation and Health. 2018;5(4). [View at Publisher] [DOI] [Google Scholar]
40. Zarei S, Mohammad-Alizadeh-Charandabi S, Mirghafourvand M, Javadzadeh Y, Effati-Daryani FJPm. Effects of calcium-Vitamin D and calcium-alone on pain intensity and menstrual blood loss in women with primary dysmenorrhea: A randomized controlled trial. Pain Medicine. 2017;18(1):3-13. [View at Publisher] [DOI] [PMID] [Google Scholar]
41. Grandi G, Del Savio MC, Melotti C, Feliciello L, Facchinetti FJGE. Vitamin D and green tea extracts for the treatment of uterine fibroids in late reproductive life: A pilot, prospective, daily-diary based study. Gynecological Endocrinology. 2022;38(1):63-7. [View at Publisher] [DOI] [PMID] [Google Scholar]
42. Kadoura S, Alhalabi M, Nattouf AHJRJoP, Technology. Effect of calcium and vitamin D supplements as an adjuvant therapy to metformin on lipid profile in vitamin D deficient/insufficient polycystic ovary syndrome patients: A Randomized, Placebo-Controlled Clinical Trial. Advances in Pharmacological and Pharmaceutical Sciences. 2019;12(5):2327-32. [View at Publisher] [DOI] [PMID] [Google Scholar]
43. Tartagni M, Cicinelli MV, Tartagni MV, Alrasheed H, Matteo M, Baldini D, et al. Vitamin D supplementation for premenstrual syndrome-related mood disorders in adolescents with severe hypovitaminosis D. J Pediatr Adolesc Gynecol. 2016;29(4):357-61. [View at Publisher] [DOI] [PMID] [Google Scholar]
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