Volume 20, Issue 1 (4-2023)                   J Res Dev Nurs Midw 2023, 20(1): 8-10 | Back to browse issues page

XML Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Barati L, Khatami S, Valizadeh M, Khoddam H. Assessing the efficacy of 10% oral dextrose in reducing pain in infants during venipuncture: A randomized controlled clinical trial. J Res Dev Nurs Midw 2023; 20 (1) :8-10
URL: http://nmj.goums.ac.ir/article-1-1424-en.html
1- Neonatal and Children's Health Research Center, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
2- Taleghani Hospital, Golestan University of Medical Sciences, Gorgan, Iran.
3- Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran. , khoddam@goums.ac.ir
Abstract:   (580 Views)
Background: Available evidence on the efficacy of sweet solutions for reducing pain in infants is insufficient. This study aimed to assess the effects of 10% oral dextrose on the pain of infants during venipuncture.
Methods: This randomized controlled clinical trial was done on 60 infants undergoing venipuncture. Eligible infants were randomly assigned into an intervention and control group. Two minutes before venipuncture, 2 ml of 10% oral dextrose solution and 2 ml of water were given to the intervention and control groups, respectively. The infants' pain intensity during the procedure was measured by two independent experts based on the Face, Legs, Activity, Cry, and CONSOL ability Behavioral Pain Scale. Data were analyzed using independent t-test and ANOVA tests. A P-value of ≤0.05 was considered statistically significant.
Results: The mean (±standard deviation) age of infants in the intervention and control groups were 6.37 (2.96) and 9.03 (3.10) months, respectively (P0.05). In addition, the standardized mean difference in pain score between the two groups was -0.2 (95% confidence interval: -0.30 to 0.71). Despite a significant difference (P=0.003) in the pain score between females and males, the effect of intervention after gender effect correction was not statistically significant.
Conclusion: Using 2 ml of 10% oral dextrose 2 minutes before venipuncture has a weak and non-significant effect on the pain of infants. Based on the effect size and 95% confidence interval, conducting further trials with a larger study population is recommended.
Full-Text [PDF 483 kb]   (89 Downloads)    
Type of Study: Original Article | Subject: Nursing

1. Oh SH, Kim IA, Jin H. Optimal dextrose concentration for pain control in healthy newborns during hepatitis B vaccination. Neonatal Medicine. 2018;25(2):72-7. [view at publisher] [DOI] [google scholar]
2. Ranjbar A, Bernstein C, Shariat M, Ranjbar H. Comparison of facilitated tucking and oral dextrose in reducing the pain of heel stick in preterm infants: a randomized clinical trial. BMC pediatrics. 2020; 20:1-9. [view at publisher] [DOI] [google scholar]
3. Birnie KA, Noel M, Chambers CT, Uman LS, Parker JA. Psychological interventions for needle‐related procedural pain and distress in children and adolescents. Cochrane Database of Systematic Reviews. 2018(10):CD005179. [view at publisher] [DOI] [google scholar]
4. Koukou Z, Theodoridou A, Taousani E, Antonakou A, Panteris E, Papadopoulou S-S, et al. Effectiveness of Non-Pharmacological Methods, Such as Breastfeeding, to Mitigate Pain in NICU Infants. Children. 2022;9(10):1568. [view at publisher] [DOI] [google scholar]
5. Gomes PPdS, Lopes APdA, Santos MSNd, Façanha SMdA, Chaves EMC. Non-pharmacological measures for pain relief in venipuncture in newborns: description of behavioral and physiological responses. BrJP. 2019;2(2):142-6. [view at publisher] [DOI] [google scholar]
6. Gouin S, Gaucher N, Lebel D, Desjardins MP. A Randomized Double-Blind Trial Comparing the Effect on Pain of an Oral Sucrose Solution vs. Placebo in Children 1 to 3 Months Old Undergoing Simple Venipuncture. The Journal of emergency medicine. 2018;54(1):33-9. [view at publisher] [DOI] [google scholar]
7. Wade C, Frazer JS, Qian E, Davidson LM, Dash S, te Water Naudé A, et al. Development of locally relevant clinical guidelines for procedure-related neonatal analgesic practice in Kenya: a systematic review and meta-analysis. The Lancet Child & Adolescent Health. 2020;4(10):750-60. [view at publisher] [DOI] [google scholar]
8. Ghaderi F, Ahmadbeigi M, Vossoughi M, Sardarian A. The efficacy of administrating a sweet‐tasting solution for reducing the pain related to dental injections in children: A randomized controlled trial. International Journal of Paediatric Dentistry. 2021;31(2):184-190. [view at publisher] [DOI] [google scholar]
9. Harrison D, Larocque C, Bueno M, Stokes Y, Turner L, Hutton B, et al. Sweet solutions to reduce procedural pain in neonates: a meta-analysis. Pediatrics. 2017;139(1). [view at publisher] [DOI] [google scholar]
10. Stevens B, Yamada J, Campbell-Yeo M, Gibbins S, Harrison D, Dionne K, et al. The minimally effective dose of sucrose for procedural pain relief in neonates: a randomized controlled trial. BMC pediatrics. 2018;18(1):1-8. [view at publisher] [DOI] [google scholar]
11. Trottier ED, Doré-Bergeron M-J, Chauvin-Kimoff L, Baerg K, Ali S. Managing pain and distress in children undergoing brief diagnostic and therapeutic procedures. Paediatrics & child health. 2019;24(8):509-521. [view at publisher] [DOI] [google scholar]
12. Lempinen H, Pölkki T, Kyngäs H, Kaakinen P. Feasibility and Clinical Utility of the Finnish Version of the FLACC Pain Scale in PICU. Journal of Pediatric Nursing. 2020;55:211-16. [view at publisher] [DOI] [google scholar]
13. Crellin DJ, Harrison D, Santamaria N, Huque H, Babl FE. The psychometric properties of the FLACC scale used to assess procedural pain. The Journal of Pain. 2018;19(8):862-72. [view at publisher] [DOI] [google scholar]
14. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Hillsdle. Erlbaum. Conner, BE 1988. [view at publisher] [google scholar]
15. Collados‐Gómez L, Ferrera‐Camacho P, Fernandez‐Serrano E, Camacho‐Vicente V, Flores‐Herrero C, García‐Pozo A, et al. Randomised crossover trial showed that using breast milk or sucrose provided the same analgesic effect in preterm infants of at least 28 weeks. Acta Paediatrica. 2018;107(3):436-441. [view at publisher] [DOI] [google scholar]
16. Kassab MI, Roydhouse JK, Fowler C, Foureur M. The Effectiveness of Glucose in Reducing Needle-Related Procedural Pain in Infants. Journal of Pediatric Nursing. 2012;27(1):3-17. [view at publisher] [DOI] [google scholar]
17. Soltani S, Zohoori D, Adineh M. Comparison the effectiveness of breastfeeding, oral 25% dextrose, kangaroo-mother care method, and EMLA cream on pain score level following heal pick sampling in newborns: a randomized clinical trial. Electronic physician. 2018;10(5):6741-6748. [view at publisher] [DOI] [google scholar]
18. Nikrouz L, Rostami S, Alijani Renani H, Rasekh A, Naghizadeh MM. Comparing the Effect of Breast-Feeding and Oral Glucose on Infants Vaccination Pain. JABS. 2014;4(2): 225-232. [view at publisher] [google scholar]
19. Dilen B, Elseviers M. Oral glucose solution as pain relief in newborns: results of a clinical trial. Birth. 2010;37(2):98-105. [view at publisher] [DOI] [google scholar]
20. Nayak R, Nagaraj KN, Gururaj G. Prevention of Pain During Screening for Retinopathy of Prematurity: A Randomized Control Trial Comparing Breast Milk, 10% Dextrose and Sterile Water. The Indian Journal of Pediatrics. 2020;87(5):353-8. [view at publisher] [DOI] [google scholar]
21. Jatana S, Dalal S, Wilson C. Analgesic effect of oral glucose in neonates. Medical Journal Armed Forces India. 2003;59(2):100-104. [view at publisher] [DOI] [google scholar]
22. Harrison D, Larocque C, Reszel J, Harrold J, Aubertin C, Dowling D, et al. Be Sweet to Babies during painful procedures. Advances in Neonatal Care. 2017;17(5):372-80. [view at publisher] [DOI] [google scholar]
23. Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, Beyene J, et al. Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review. Archives of disease in childhood. 2010;95(6):406-13. [view at publisher] [DOI] [google scholar]
24. Friedrichsdorf SJ, Goubert L. Pediatric pain treatment and prevention for hospitalized children. Der Schmerz. 2021;35:195-210. [view at publisher] [DOI] [google scholar]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Research Development in Nursing and Midwifery

Designed & Developed by : Yektaweb