Background and Objective: Hypertension in patients with non-alcoholic fatty liver disease is the main cause of cardiovascular disease . The present study aimed to determine the effect of Berberis vulgaris fruit extract on blood pressure and weight in patients with non-alcoholic fatty liver disease.

  Material and Methods: This clinical trial was conducted in 2011 on 80 patients with non-alcoholic fatty liver disorder, including 32 males (40%) and 48 females (60%), who were randomly assigned into case and control group. The case group were given two capsules (750 mg) including berberis vulgaris extract every day for three months, while the subjects of control group treated by placebo. Blood pressure and weight of baseline and those of after three month were assessed and analyzed by SPSS software Ver.17, using paired t-test and independent t-test (p≤0.05).

  Results: the mean of weight decreased from 80.23±11.68 (baseline) to 78.71±11.31 (End of the third month), which was statistically significant compared to control group (P<0.001). The Mean of systolic and diastolic blood pressure was significant compared to control group. (p<0.05).

  Conclusion: Considering the significant decrease in weight and blood pressure, further studies with larger sample size are needed to generalize crucially the results. This extract can be introduced to treat overweight and hypertension in patients with non-alcoholic fatty liver disease.

  Background and Objective: Non-alcoholic fatty liver disease is the most prevalent cause of hepatic related problems. , which has not been introduced any crucial treatment for it so far. Insulin resistance and oxidative stress are the most important risk factors for this disease. As anti-oxidant and insulin resistance decreasing effect of Cinnamon has been shown in prior studies, we carried out this research to determine the effect of cinnamon on lipid profile, liver enzymes, insulin resistance and hs-CRP inflammatory factor in patients with nonalcoholic fatty liver.

  Material and Methods: this clinical trial was conducted on 50 patients with fatty liver, selected on the basis of including criteria. The Intervention group was given 1.5 gram Cinnamon and placebo group taken placebo for 12 weeks. Lipid profile (triglycerides, total cholesterol, HDL and LDL), fasting blood glucose, serum insulin , hs - CRP inflammatory factor, liver enzymes (ALT and AST and GGT), insulin resistance index (HOMA-IR) and insulin sensitivity (QUICKI), diet, physical activity and anthropometric indices were measured in the beginning and end of the study. Statistical analysis was performed by SPSS software, using Covariance, Students t-test, Paired t-test, Wilcoxon and Mann-Whitney.

  Results: A significant decrease in HOMA, fasting blood glucose, total cholesterol, ALT, AST, GGT and hs-CRP , and a significant increase in Quicki were seen in Cinnamon group (p <0.05). The change of LDL cholesterol in both groups was significant (p <0.05), whereas the reduction of HDL cholesterol wasn’t significant ­­ (p=0.130).

  Conclusion: based on the results, the use of Cinnamon may be effective in the patients with non-alcoholic fatty liver disease.