Palliative care is essential to Universal Health Coverage and reducing serious health-related suffering, yet major educational gaps persist for nurses across the Eastern Mediterranean Region. Although nurses deliver palliative care in hospitals, communities, and homes, many report insufficient knowledge, skills, and confidence—especially in end-of-life communication, complex symptom management, and psychosocial–spiritual support. These gaps are driven by limited curricular integration, shortages of trained faculty, resource constraints, and scarce post-graduation training. Digital and virtual education models (e.g., Project ECHO, web-based modules, and virtual simulation/VR) offer scalable solutions by improving access, reducing time and cost barriers, and strengthening competence and self-efficacy. However, implementation must be aligned with local health-system realities and adapted to Middle Eastern cultural and religious contexts, particularly family-centered decision-making and norms around sensitive discussions. Sustained investment in educator preparation, infrastructure, and ongoing mentorship is required to embed culturally responsive virtual palliative care education within nursing curricula.