en Original Article <strong>Background:</strong> Since health-promoting lifestyle is an important determinant of health status, this study aimed to compare the health-promoting lifestyle in medical and non-medical students of Guilan, Iran.<br> <strong>Methods:</strong> This is a cross-sectional study with a descriptive-analytical approach that was performed on 1319 students of medical sciences and non-medical sciences in Guilan, 2014. The data collection tool was 52-item HPLP &Pi; in six dimensions (health responsibility, physical activity, nutritional habits, stress management, spiritual growth, and interpersonal relationships). Data was analyzed using one-way ANOVA, T-test, and Kruskal&ndash;Wallis test.<br> <strong>Results:</strong> The mean health-promoting lifestyle among students of Guilan University and Guilan University of Medical Sciences was (129.5&plusmn; 7.17) and (128.1&plusmn; 19), respectively. There was a significant difference between the two studied population in terms of health responsibility (p= 0.0001). Students of medical sciences had 3.2 times more favorable health promoting lifestyle (OR = 3.123, 95% CI = 1.57-6.3), married students 6.1 times (OR= 1.55, 95% CI = 1.05-2.32), students with mothers with under diploma degree 2.6 times (OR= 2.6 95% CI = 1.49-4.62), students with fathers with diploma 1.7 times (OR = 1.7, 95% CI = 1.2-2.56), and physical education and sports science students 5.8 times (OR = 8.5, 95% CI = 3.42- 20.95) had a more optimal health promoting lifestyle.<br> <strong>Conclusion:</strong> In the present study, students&#39; health-promoting lifestyles are in an unfavorable condition. Since the students in the future will be responsible for managing different sectors of the country and will play a role in changing the other health-promoting behavior of other strata of the society, it is important to consider their health-promoting lifestyles by providing facilities and eliminating the shortcomings.<br> <strong>Keywords:</strong> lifestyle, health-promoting, students lifestyle, health-promoting, students 45 52 http://nmj.goums.ac.ir/browse.php?a_code=A-10-908-3&slc_lang=en&sid=1 Afsaneh Pasha 10031947532846004667 10031947532846004667 No Master of Health Nursing, School of Nursing and Midwifery Sedigheh Pakseresht paksersht@yahoo.com 10031947532846004668 10031947532846004668 Yes Associate Professor of Women Health Promotion/Community Health, Social Determinants of Health Research Center (SDHRC) Komeil Rezaie 10031947532846004669 10031947532846004669 No Master of Health Nursing, School of Nursing and Midwifery Sedigheh Rezaie 10031947532846004670 10031947532846004670 No Master of Midwifery, School of Nursing and Midwifery Ehsan KazemNejad 10031947532846004671 10031947532846004671 No Associate Professor of Biostatistics